Five people died in a large-scale traffic accident on Highway 1, between the Latrun and Anava interchanges, in which 15 other people were wounded, several in critical and serious condition.
In the crash a truck and bus collided, leading to the large number of wounded. The bus was identified as being of the 402 line heading from Jerusalem to Bnei Brak.
All of the wounded have been evacuated to the hospital.
Magen David Adom (MDA) has declared the crash a mass-casualty incident, and large medical forces have been dispatched to the site.
Ichud B'Ichud medical volunteer Daniel Ben-David said, "when I reached the scene I came across a serious crash involving an Egged bus and a truck."
"Some of the bus passengers were trapped and unconscious, and more than 20 additional wounded were conscious, I asked for help from additional volunteers," added Ben-David.
"At this point the forces are still streaming into the area to help with initial medical treatment for the wounded, some of whom are still trapped in the bus."