"We are all shocked at the horrific massacre in Orlando," Netanyahu stated at the start of the weekly cabinet meeting, which was postponed from Sunday in honor of Shavuot.
"On behalf of the government and people of Israel, I would like to again express our condolences to the American people and the families at this especially difficult time."
"This terror threatens the entire world and it is necessary – first of all – that the enlightened countries urgently unite to fight it," he added. "We stand shoulder to shoulder with the American people."
50 people were murdered and 53 wounded – many of them seriously – in the attack by a Muslim terrorist who pledged allegiance to the Islamic State (ISIS) jihadist group.
The gun rampage was the worst shooting spree in American history.