The driver, 46, was slightly wounded by shrapnel in his hand, but managed to continue driving to a nearby IDF base, where he was treated by the Ephraim Brigades's medics.
He was later brought by a Megan David Adom ambulance to Meir Hospital in Kfar Saba in light condition.
The terrorists, driving a white Fiat Punto with Israeli license plates, fled after the shooting, in the direction of the Gilead junction. IDF forces are conducting searches in the area.
The attack joins a long list of terrorist incidents that have occurred recently on the roads of Judea and Samaria and in Jerusalem.
Last Wednesday, Arab terrorists threw a firebomb at a Border Police vehicle in the A-Tur neighborhood of Jerusalem.
Border Police officers inside the car managed to extricate themselves from the vehicle before it caught on fire and burned down. A 23-year-old officer sustained minor smoke inhalation in the incident and was brought to Shaare Zedek Medical Center in the capital.
On Saturday night, an Arab driver tried to run over a group of soldiers who were standing at the Hakvasim junction on Mount Hevron. One of the soldiers was lightly injured in his foot.
"The shooting at Jit Intersection near Kedumim joins a chain of attacks against civilians and soldiers," Hanenal Dorani, head of the Kedumim Regional Council, said in response to the attack.
"I call on the Israeli government to intensify our hold on Judea and Samaria through building permits in all of the communities and to strengthen the IDF to continue to act vigorously in places from which terrorist come."